RDKit All seems fine (Note: -Python 2.7 is no longer supported - use Python 3 instead) R Releases for either Intel or Apple Silicon Python works fine on Apple Silicon and is "mad fast!". Python Python 2.7 is no longer included - use Python 3 instead PYMOL On Intel Macs with macOS 12, PyMOL works fine, no known issues. I then updated again to Monterey - still working fine. Orca Orca and openmpi working fine under Big Sur. Available on Linux, Microsoft Windows and Mac OS X, including Apple Silicon Macs. NAG Fortran compiler Robust and highly tested Fortran Compiler, valued for its checking capabilities and detailed error reporting. MOE Initial tests showed no issues with this version. Microsoft Office any Office for Mac which works with ‘Big Sur’ macOS v11 is OK with ‘Monterey’. Mathematica Mathematica running fine on MacOS Monterey On Apple silicon Macs, MATLAB runs using the Rosetta 2 environment. Matlab MATLAB is compatible with macOS 12 (Monterey) Running MATLAB and Simulink on Apple silicon Macs is supported in MATLAB R2020b Update 3 and newer. IDL Version 8.8.1 adds support for M1 Macs
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